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malignant pleural mesothelioma(A.Bakhshandeh).pdf

软件类型:国产软件 授权方式:共享软件 界面语言:简体中文 软件大小:0.16 MB 运行环境:Win2003,WinXP,Win2000,Win9X 软件等级:★★★☆☆ 发布时间:2011-11-21 官方网址:http:// 演示网址:http:// 下载次数:
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Abstract

We performed a phaseIIstudy combining 41.8 8 C whole body hyperthermia with ICE chemotherapy,i.e.ifosfamide(5 g/m

2

),
carboplatin(300 mg/m

2

)andetoposide(150 mg/m

2

on days2and3),administerede v ery4 weeks,forpatients with malignantpleural
mesothelioma. Of27 chemona¨i
v e,non-metastatic patientsenrolled,25 patients weree v aluableforresponse. O v erallresponserate
was20% (fi
v e partialremissions;95% CI8.9  / 39.1%). Median sur v i v altimefrom thestartoftreatmentforallpatients was76.6
weeks(95% CI65.4
 / 87.8 weeks).Progressionfreesur v i v alforallpatients measured 29.6 weeks(95% CI24.4  / 34.7 weeks).Oneyear
o
v erallsur v i v al was 68% and 2 year o v erallsur v i v al was 20%. Majortreatmenttoxicitiesincluded grade 3/4 neutropenia and
thrombocytopeniain 74 and 33% oftreatmentcycles,respecti
v ely. One patient died dueto sepsis. These promising results are
consistent with continued clinicalin
v estigation;a phaseIIIclinicaltrial with whole body hyperthermia astheindependent v ariable
hasbeeninitiated.

#
2002 Else v ier ScienceIreland Ltd. Allrightsreserved.

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